Synthesis, Characterization, and Subacute Toxicity of Hydrazide-Iron Complex in Rats

Amal Hussein  Anatheil; Wafa Saleh  Abdulredha; Wasan K. Damdoom

doi:10.51699/cajotas.v6i3.1581

Amal Hussein Anatheil Department of Pharmaceutical Chemistry, College of Pharmacy, University of Thi-Qar, 64001, Thi-Qar, Iraq
Wafa Saleh Abdulredha Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Thi-qar, Thi-qar 64001, Iraq
Wasan K. Damdoom Department of Pharmaceutical Chemistry, College of Pharmacy, University of Thi-Qar, 64001, Thi-Qar, Iraq

DOI: https://doi.org/10.51699/cajotas.v6i3.1581

Keywords: Hydrazide, Iron(III) complex, Subacute toxicity, Liver function, Hematology

Abstract

In this study, a hydrazide derivative and its iron (III) complex were synthesized and characterized using IR, MS, NMR, and elemental analysis. Subacute oral toxicity was assessed in male Wistar rats over 28 days. Biochemical and hematological parameters indicated dose-dependent effects on the liver and kidneys, including elevated ALT and creatinine levels. The iron complex group showed reduced RBC and hemoglobin with mild leukocytosis. These results suggest potential systemic toxicity at higher doses, highlighting the need for further investigation.

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